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Genetic health education is one of the corner stones and part of the scope of CMG activities. CMG is the only center of the whole region which provides professional medical genetic education and training. The highly qualified and dedicated members of our center provides genetic educational program to support medical education in clinical genetics, genetic counselling, and modern molecular and personalized medicine. Our specialists have a long history of teaching experience in university education of Armenia, including Yerevan State Medical University (YSMU), Yerevan State University, Russian-Armenian (Slav) University (RAU), National Institute of Health Care of Armenia.

Currently, courses of medical genetics are provided for undergraduate, graduate and postgraduate students as well as health care professionals at the department of Medical genetics of YSMU and RAU on the basis of the CMG.

Medical genetics is recognised a medical speciality in Europe, and special recommendations are developed by the European Health Committee (CDSP) and adopted by member states, including Armenia. The CMG as the leader of providing genetic services in the region has taken the responsibility of the provision of postgraduate programs and life-long training programmes of medical genetics. Currently, we are reforming our education programs at the YSMU and RAU and are developing a residency training program of Clinical Genetics in the YSMU and a master program of Genetic Counselling in the RAU. This Tempus MedGen project will allow to harmonize the teaching of Medical Genetics as an obligatory medical discipline for all medical and biomedical students and to establish a hub for international education and research programs and will contribute to the overall quality of healthcare in Armenia. The wider objective of MedGen project is the development and implementation of solid basis with active workforce of medical genetics corresponding to EU educational and professional standards in medical genetics in Armenian and reinforcement of international cooperation capacity.

The CMG has a rich history of successful national and international research and development projects directed toward research improvement, fundamental research, and genetic service-sector development. The current mandate of the CMG in Armenia is to support research on the human genome and on all aspects of human genetics related to health and disease, including the translation of knowledge into health policy and practice, and the societal implications of genetic discoveries. The actual strategy adopted by the centre is to provide solid support for deliberately restricted areas of focus for scientific research, which are considered to be of a high priority in Armenia. Vision of the CMG is to become the leading Armenian and regional institution for the advocacy, development and support of all fields of human genetic research, maximizing the health opportunities offered by this knowledge to the benefit of communities.

In addition to research projects, development of medical genetic services is carried out through active participation in an integrated network for the study of the human genome and genetic testing: European Network of Excellence, Eurogentest, and Orphanet, the aim of which is the creation of tools and databases of genetic data, improvement of infrastructure and molecular genetic, genomic, cytogenetic, and biochemical services. Research developments of the CMG are based on the achievements in the study of the human genome, which are widely used to study the molecular nature, accurate and early diagnosis, prevention and treatment of a wide range of hereditary diseases.

List of Projects:

2014 - Present

ISTC (International Science and Technology Centre) research project Nuclear and mitochondrial genetic variants and molecular bases of mitochondrial OXPHOS diseases Collaborators: National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Japan Kennedy Center, Copenhagen University Hospital, Denmark Wellcome Trust Centre for Mitochondrial Research, Newcastle University, UK Eunice Kennedy-Shriver National Institute of Child Health and Human Development, NIH, USA National Bureau of Expertises of Armenia Akhali Sitsotskhle medical center, Georgia

Swiss National Science Foundation (SNSF) SCOPES research project Genetics of Human Disorders of Sexual Development Collaborators: Department de Medecine Genetique & Developpement Faculte de Medecine Universite de Geneve, Switzerland National Academy of Sciences of Ukraine Polish Academy of Sciences

Mapping and functional characterization of structural chromosomal and genomic rearrangements (translocations, inversions, copy number variations) in relation to protein-coding genes; non-coding RNA genes (ncRNA), including microRNAs; long range position effects and epigenetic modifications. Collaborator: Willelm Johansen Center for Functional Genome Research, University of Copenhagen, Denmark

2008 - 2013

EC FP7-INCO ERAWIDE project: Integrating Armenia into European research Area Collaborators: The Danish Cancer Society, DenmarkEuropean Centre for Knowledge and Technology Transfer (EUROTEX), Belgium

FP7-Health SICA project CHERISH “Improving diagnoses of mental retardation in children in Eastern Europe and Central Asia through genetic characterization and bioinformatics/statistics” Collaborators: University of Bologna, Italy University of Tartu, Estonia Vilnius University, Lithuania Charles University Prague, Czech Republic Poznan University of Medical Sciences, Poland Institute of Molecular Biology and Genetics of the National Academy of Sciences, Ukraine The Cyprus Institute of Neurology and Genetics, Cyprus Institute of Medical Genetics, Russian Academy of Medical Sciences, Russia European Genetics Foundation

ISTC (International Science and Technology Centre) research grant “Molecular basis of the autoinflammation developed in FMF and related disorders” Collaborators: Bases Moleculaires et Cellularies des Maladies Genetiques, Institut National de la Santeet de la Recharche Medicale, France Department of Pediatrics, University of Genoa, Italy

Armenian State Thematic Research grant “CNV-molecular karyotyping analysis of mental retardation”

Armenian National Science & Education Fund (ANSEF) research grant: “Genetic basis of FMF-related disorders”

Armenian State Thematic Research grant “Role of diagnosis of hyperhomocysteinemia for the prevention of obstetrics with complications”

Armenian State Thematic Research grant “Genetic analysis of patients with FMF”

Armenian State Thematic Research grant “Mutation screening of breast cancer patients of high genetic risk”

2002 - 2006

US Civilian Research and Development Foundation (CRDF) R&D grant “Development of a Commercial Kit for Identification of 6 Major Mutations in the MEFV Gene”

Armenian National Science & Education Fund (ANSEF) research grant: “Study of BORIS gene expression in breast cancer cells”

NATO Collaborative linkage grant “Diagnostics of Familial Mediterranean Fever and related diseases” “Armenia” Foundation of Switzerland research grant “Detection of genetic risk factors for cerebrovascular and coronary heart disease”

1998 - 2001

National Foundation of Science and Advanced Technologies of Armenia R&D grant “Introduction of Cytogenetic Workstation”

Armenian National Science & Education Fund (ANSEF) research grant: “Development of Medical Genetics and Molecular Diagnosis in Armenia”

Gulbenkian Foundation’s grant “Developing and improving medical genetic services in Armenia”