Azoospermia and Oligospermia - Y chromosome microdeletions test

After the Klinefelter syndrome, Y-chromosomal microdeletions are the second most frequent genetic cause of male infertility. Microdeletions occur in about one in 4000 men in the general population but its frequency is significantly increased among infertile men. Azoospermic men have a higher incidence of microdeletions than oligozoospermic men and consequently deletion frequency found in different laboratories may vary from 2 to 10%. The most frequent deletion type is the AZFc region deletion (∼80%) followed by AZFa (0.5–4%), AZFb (1–5%) and AZFbc (1–3%) deletion. Deletions which are detected as AZFabc are most likely related to abnormal karyotype such as 46,XX male or iso(Y). 

Diagnosis of a microdeletion of the Y chromosome permits the cause of the patient's azoospermia/oligozoospermia to be established and to formulate a prognosis.CMG’s Y-chromosome microdeletion test provides detection of all seven markers of AZFa, AZFb and AZFc regions required by the European Academy of Andrology (EAA) and the European Molecular Genetics Quality Network (EMQN).

For further information please contact:
Tel.: (+374 10) 544367
Fax: (+374 10) 544366

Գին՝ 15 000 AMD