Routine chromosomes and FISH trisomy screen for 13, 18, and 21 are available for prenatal samples (amniotic fluid). Amniocentesis is performed between the 15th-20th weeks of pregnancy. By karyotyping we analyze chromosomal abnormalities.
- Couples at increased risk of having infants with abnormal chromosomes
- advanced maternal age- 35 years or older
- previous child with a chromosome disorder such as Down syndrome
- one member of the couple is known to carry a chromosome rearrangement
- in certain cases, relatives of a child with a chromosome disorder
- pregnancies at increased risk of chromosome defects due to finding of fetal defects on ultrasound.
- pregnancies identified by prenatal serum screening to be at increased risk for neural tube defects or chromosome defects.
Specimen requirement - 20 to 30 ml amniotic fluid collected in 2 to 3 sterile tubes. The first few mls of fluid should be discarded as they increase the likelihood of maternal cell contamination. Specimen should be kept at room temperature; do not freeze or refrigerate. Specimen should be sent at the laboratory immediately. The following information should accompany the specimen: patient's name, physician's name, date collected, EGA by ultrasound, LMP (if available), maternal age, and indication for study.
Reporting time - Cell culture can take 1-4 weeks and may lengthen turnaround time. FISH results are usually available within 2-3 days.
For further information please contact:
Tel.: (+374 10) 544367
Fax: (+374 10) 544366