Human bone turnover or remodeling is a balanced process of bone formation and bone resorption. Most of the organic matrix of bone consists of Type I collagen. This is a helical protein that is cross-linked at both the C-terminal and N-terminal ends of the molecule. A fragment of collagen at its C-terminal end changes its nature as bone ages, whereby its constituent alpha form of aspartic acid converts to the beta form. This fragment or telopeptide is called Beta-CTx.
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