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Laboratory Services
Clinical Laboratory

Clinical Laboratory uses sophisticated equipment and biochemical, microscopic and immunological techniques to analyze blood, tissues and other medical specimens. Clinical laboratory provides essential information to physicians and other health care professionals about the presence, extent, or absence of diseases, as well as effectiveness of treatment. Clinical laboratory test results are extremely important for diagnosis and treatment. We offer wide-range of reliable testing of the highest quality for the diagnosis and clinical care of our patients.

Analyses
Complete Blood Count +DIFF (CBC) 3 000 AMD
Erythrocyte sedimentation rate (ESR) 1 000 AMD
Insulin 7 000 AMD
Proinsulin 7 000 AMD
C-peptide 8 000 AMD
Vitamin D total 12 000 AMD
B-CrossLaps 8 000 AMD
N-MID Osteocalcin 6 500 AMD
Adrenocorticotropic hormone (ACTH) 7 000 AMD
Cortisol 6 000 AMD
Dehydroepiandrosterone sulfate (DHEA-S) 6 000 AMD
Estradiol (E2) 6 000 AMD
Follicle-Stimulating Hormone (FSH) 6 000 AMD
Luteinizing hormone (LH) 6 000 AMD
Progesterone 6 000 AMD
Prolactin 6 000 AMD
Testosterone 6 000 AMD
Anti-Mullerian Hormone (AMH) 13 000 AMD
17OH Progesterone 6 000 AMD
Total Triiodothyronine (T3) 6 000 AMD
Total Thyroxine (T4) 6 000 AMD
Thyroid-Stimulating Hormone (TSH) 6 000 AMD
Thyroglobulin (TG) 9 000 AMD
Antibodies Against Thyroglobulin (Anti-TG) 7 000 AMD
Antibodies Against Thyroperoxidase (Anti-TPO) 7 000 AMD
Free Triiodothyronine (Т3 free) 6 000 AMD
Free Thyroxine (Т4 free) 6 000 AMD
Parathyroid hormone (PTH) 6 500 AMD
AFP (Alpha-Fetoprotein) 6 000 AMD
Pregnancy-associated plasma protein (A PAPP-A) 8 500 AMD
Free Beta-Subunit of Human Chorionic Gonadotropin (Free –BHCG) 10 000 AMD
Program ”Prognoz” for the screening of Down Syndrome 5 000 AMD
CA 15-3 - Cancer Antigen 9 000 AMD
CA 125 - Cancer Antigen 9 000 AMD
CEA - Carcinoembryonic antigen 9 000 AMD
CA-19-9 - Cancer Antigen 9 000 AMD
PSA (Prostatic Specific Antigen) - Prostate Cancer 7 000 AMD
Beta Human Chorionic Gonadotropin (hCG +β) 6 500 AMD
Calcitonin 12 000 AMD
Herpes Simplex virus 1 IgG (HSV1 IgG) 6 000 AMD
Herpes Simplex virus 1 IgM (HSV1 IgM) 6 000 AMD
Herpes Simplex virus 2 IgG (HSV2 IgG) 6 000 AMD
Herpes Simplex virus 2 IgM (HSV2 IgM) 6 000 AMD
Toxoplasma IgG (Toxo IgG) 6 000 AMD
Toxoplasma IgM (Toxo IgM) 6 000 AMD
Toxoplasma IgG Avidity 15 000 AMD
Cytomegalovirus IgG (CMV IgG) 6 000 AMD
Cytomegalovirus IgM (CMV IgM) 6 000 AMD
CMV IgG Avidity 15 000 AMD
Chlamydia IgG (Chl IgG) 6 000 AMD
Chlamydia IgA (Chl IgA) 6 000 AMD
Rubella IgG 6 000 AMD
Rubella IgM 6 000 AMD
Helicobacter pylori IgG (HP IgG) 8 500 AMD
Hepatitis B (HbsAg surface antigen) 7 500 AMD
Hepatitis C (Anti-HCV) 7 500 AMD
HIV combi (HIV1, HIV2 total antibodies) 5 000 AMD
Anti-Phospholipid Screen (APS) 12 000 AMD
Vitamin B12 7 500 AMD
Ferritin 5 000 AMD
Semiquantitative analysis of Urea- and Micoplasma 10 000 AMD
Fungal nail infection analysis 3 000 AMD
Demodicosis analysis 3 000 AMD
Antibiotic sensitivity testing for Urea- and Micoplasma 10 000 AMD
Syphilis (Total antibodies to Treponema pallidum) 5 000 AMD
Clinical Common Urine Examination 2 200 AMD
Testosterone free 6 000 AMD
Antibodies Against TSH Receptor (Anti-TSHR) 12 000 AMD
Smear test 3 000 AMD
Anti-CCP: cyclic citrullinated peptide antibody 8 000 AMD
Giardia Lamblia - IgM, IgG, IgA 6 000 AMD
Epstein-Barr virus (EBV) - IgM, IgG 6 000 AMD
Antibodies against Epstein-Barr virus nuclear antigen (EBNA) 6 000 AMD
HE4 antigen (ROMA) 9 000 AMD
Biochemical Laboratory

Biochemical part. Genetic disorders have become a focal point in laboratory medicine. Approximately one thousand inborn errors of metabolism have been identified to date. Our Clinic covers the biochemical diagnosis of these errors. And is defined as first concerned with the evaluation and diagnosis of patients and families with inherited metabolic disease, monitoring of treatment, and distinguishing heterozygous carriers from non-carriers by metabolite and enzymatic analysis of physiological fluids and tissues. The Biochemical Laboratory is an interdisciplinary group of, geneticists biochemists physicians and laboratorians with a mission to provide biochemical testing and result interpretation of the highest quality for the diagnosis, study and clinical care of patients with disorders of metabolism. We routinely perform qualitative detection and quantitative determination of diagnostic markers based on a variety of manual and automated methods. Our Biochemical Laboratory faculty and staff strive to provide clinicians and families with an accurate and rapid confirmatory diagnosis as well as follow-up testing for newborns suspected of having a metabolic disorders. Our Clinical Biochemical Laboratory provides comprehensive metabolic testing for the diagnosis and management of patients with a wide variety of inborn errors of metabolism. We serve the patients of our Clinic, as well as a growing number of outreach clients. We strive to: - Provide the highest quality of laboratory testing and patient care - Offer expert test interpretations and consultative services to physicians - Translate new discoveries into more efficient patient testing - Training the students for the next generation of clinical and laboratory scientists Laboratory of Biochemistry and Immunopathology of the Center of Medical Genetics and Primary Health Care perform 56 different tests (in area of biochemistry, hemostasis and oncology). We use a modern equipment and reagents from leading firms (DAKO, Hoffmann La Roche, Hitachi): - The Cobas c111 analyser for clinical chemistry - The Cobas c311 analyser for clinical chemistry - The Stago analyzer for coagulation study - PT_Link, etc. Our laboratory faculty and staff appreciate the trust you place in us, and we strive everyday to provide exceptional service for our referring physicians, genetic counselors and most importantly, the families they serve.

Analyses
Albumin 1 500 AMD
Total protein 1 500 AMD
Bilirubin Direct 1 000 AMD
Bilirubin Total 1 000 AMD
Bilirubin Undirect 1 000 AMD
Glucose 1 000 AMD
Uric acid 1 500 AMD
Urea 1 500 AMD
Urea nitrogen 1 000 AMD
Creatinine 1 000 AMD
Cholesterol total 1 500 AMD
High Density Lipoproteins Cholesterol (α) 1 500 AMD
Low Density Lipoproteins Cholesterol (β) 1 500 AMD
Very Low Density Lipoproteins 1 500 AMD
Triglycerides 2 000 AMD
Coefficient of atherogenety 1 000 AMD
Alkaline phosphatase (ALP) 1 500 AMD
Calcium (Ca) 1 500 AMD
Calcium Ion. (Ca++) 2 000 AMD
Sodium (Na) 1 500 AMD
Potassium (K) 1 500 AMD
γ-Glutamyltransferase (GGT) 1 500 AMD
Aspartate aminotransferase (ASAT) 1 500 AMD
Alanine aminotransferase (ALAT) 1 500 AMD
α-Amylase Total 2 000 AMD
α-Amylase pancreatic 1 500 AMD
Lactate dehydrogenase Direct (LDH-dir) 1 000 AMD
Creatin Kinase (CK) 1 000 AMD
Iron 2 000 AMD
UIBC 1 000 AMD
TIBC 1 000 AMD
Transferrin 3 000 AMD
Inorganic Phosphorus (P) 1 000 AMD
Lipase 2 000 AMD
Magnesium (Mg) 1 000 AMD
Chlorides (Cl) 1 000 AMD
Glycated hemoglobin (HbA1c) 6 000 AMD
Homocysteine 10 000 AMD
D-Dimer 8 000 AMD
Brucellosis 2 000 AMD
Brucellosis (by Wright-Heddelson method) 3 000 AMD
High sensitive C-reactive protein (CRP-HS) 3 000 AMD
C-reactive protein (CRP-LX) 2 000 AMD
Rheumatoid Factor (RF) 2 000 AMD
Antistreptolysin (ASLO) 2 000 AMD
Prothrombin Index 1 500 AMD
Prothrombin Time (PT) 1 500 AMD
International Normalized Ratio (INR) 1 000 AMD
Fibrinogen (F) 1 500 AMD
Activated Partial Thromboplastin Time (aPTT) 2 000 AMD
Thrombin Time (TT) 1 500 AMD
Anticoagulant (LA) 5 000 AMD
Antithrombin III (AT III) 5 000 AMD
Acidic phosphatase (ACP) 1 500 AMD
Lactate 2 000 AMD
Calcium Ion.(Ca++), Potassium (K), Sodium (Na) 4 500 AMD
Fructosamin 3 000 AMD
Total coagulogramma 8 500 AMD
Total cholesterol (lipid) probes 9 000 AMD
Carbamazepine 6 000 AMD
Valproic Acid 6 000 AMD
Sweet test (Chloride level) 5 000 AMD
Immunopathology Laboratory

Our laboratory faculty and staff appreciate the trust you place in us, and we strive everyday to provide exceptional service for our referring physicians, genetic counselors and most importantly, the families they serve. We offer the following tests for oncology: 1. Estrogen and Progesterone receptors (method of immunohistochemistry) 2. Her-2/neu (method of immunohistochemistry, FISH) 3. Ki-67 (method of immunohistochemistry) 4. P53 receptor (method of immunohistochemistry) Immunohistochemical Testing of Estrogen and Progesterone Receptors Estrogen (ER) and progesterone (PR) receptors are nuclear hormone receptors found in certain cells throughout the body. ERs and PRs are expressed in about 70% and 60% of invasive breast cancers, respectively. These tumors are named hormone-dependent because estrogen and/or progesterone hormones affect their growth. Status of ERs and PRs must be checked as an essential part of an initial analysis of all primary breast cancers. ER and PR are weak factors for prognosis but are strong predictive factors for response to endocrine therapies. Patients with ER/PR- positive tumors tend to have a better-than-average prognosis to respond to endocrine therapy than those with ER/PR- negative tumors. Her-2/neu HER2/neu (also known as ErbB-2) stands for "Human epidermal growth factor receptor 2" and it is a protein giving higher aggressiveness in breast cancers. It is encoded by the ERBB2 gene. Approximately 15-20% of breast cancers have an amplification of the HER2/neu gene or overexpression of its protein product. Overexpression of HER2/neu in breast cancer is associated with increased disease recurrence and worse prognosis. Because of its prognostic role as well as its ability to predict response to Trastuzumab (Herceptin), breast tumors are routinely checked for overexpression of HER2/neu. HER2/neu is also used as a predictor of response to therapy such as resistance to hormonal therapy. Therefore, HER2/neu testing is not diagnostic but helps physicians to understand more about tumor’s characteristics and to choose the treatment options. Overexpression also occurs in other cancer such as ovarian cancer, stomach cancer, esophageal cancer, and biologically aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. Since January, 2011 CMG was starting additional tests for Her-2/neu FISH: Fluorescence In Situ Hybridization - uses fluorescent probes to look at the number of HER2 gene copies in the tumor cell. If there are more than 2 copies of the HER2 gene, then the cancer is HER2 positive. Ki-67: Proliferation is a key feature of the progression of tumors and is now widely estimated by the immunohistochemical assessment of the nuclear antigen Ki-67. The Ki-67 is a marker of proliferation. High Ki-67 is a sign of poor prognosis associated with a good chance of clinical response to chemotherapy. P53 plays an important role in cell cycle control and apoptosis. Defective p53 could allow abnormal cells to proliferative, resulting in cancer. High p53 is a sign of poor prognosis associated with a bad chance of clinical response to chemotherapy. For Estrogen/Progesterone/Hercep, Ki-67, p53 immunohistoche-mical tests and FISH/CISH, please contact: Laboratory of Biochemistry and Immunopathology Tel: (+ 374) 10 544367 Fax: (+ 374) 10 544366 e-mail: arrmi@mail.ru

Analyses
Estrogen Receptor (ER) 25 000 AMD
Progesteron Receptor (PR) 25 000 AMD
Her-2-neu oncoprotein (Epidermal Growth Factor Receptor (EGFR ) Type 2) 15 000 AMD
Ki-67 (Marker of proliferation) 10 000 AMD
P53 (Marker of apoptosis) 15 000 AMD
Detection of Her2-neu oncoprotein by FISH 75 000 AMD
Estrogen, Progesteron Receptors and Her2-neu: Complex investigation 65 000 AMD
Estrogen, Progesteron Receptors and Her2-neu, Ki67: Complex investigation 75 000 AMD
Estrogen, Progesteron Receptors and Her2-neu, Ki67, p53: Complex investigation 85 000 AMD
C3c, complement 3 000 AMD
C4, complement 3 000 AMD
Immunoglobulin A 3 000 AMD
Immunoglobulin M 3 000 AMD
Immunoglobulin G 3 000 AMD